Death from Hemophagocytic Lymphohistiocytosis Syndrome Due to Generalized Hemorrhage

Dyserythropoiesis due to reactive hemophagocytic lymphohistiocytosis.

A 37-year-old man of Pakistani origin presented with a 5-week history of fever, night sweats, fatigue, nausea, vomiting, lymphadenopathy, and splenomegaly. He had similar symptoms 5 years prior with a cervical lymph node (LN) biopsy showing histiocytic necrotizing lymphadenitis or Kikuchi disease (KD). He had pancytopenia, with a neutrophil count of 0.52 3 10/L, hemoglobin count of 76 g/L, mean...

Autoimmune Lymphoproliferative Syndrome Misdiagnosed as Hemophagocytic Lymphohistiocytosis A Case Report

Autoimmune lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of apoptosis. It usually presents with chronic lymphadenopathy, splenomegaly, and symptomatic cytopenia in a child. Herein, we report a 14-year-old boy with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis who was treated before ALPS was diagnosed for the patient. This case should alert pediatricians to consi...

Severe dengue due to secondary hemophagocytic lymphohistiocytosis: A case study

Dengue, transmitted by the mosquito Aedes aegypti affects millions of people worldwide every year. Dengue induced hemophagocytic lymphohistiocytosis (HLH) is a serious condition and may prove fatal if not detected early and treated appropriately. Diagnosis of HLH is challenging and usually missed as clinical and laboratory findings are nonspecific. Moreover, the pathophysiology of the systemic ...

Acute polymyositis associated with hemophagocytic lymphohistiocytosis syndrome

Background Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease in which an exaggerated but ineffective immune response leads to severe hyper inflammation. It commonly affects infants from birth to 18 months of age, but cases in older children and adults have also been reported. Key players in HLH are activated lymphocytes and histiocytes, they infiltrate all organs and secret...

Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis.

Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder of apoptosis, most commonly due to mutations in the FAS (TNFRSF6) gene. It presents with chronic lymphadenopathy, splenomegaly, and symptomatic multilineage cytopenias in an otherwise healthy child. Unfortunately, these clinical findings are also noted in other childhood lymphoproliferative conditions, such as leukemia,...

Hemophagocytic lymphohistiocytosis secondary to histoplasmosis